Ethanone, 2-hydroxy-1-(1H-indol-5-yl)-

Ethanone, 2-hydroxy-1-(1H-indol-5-yl)- - Names and Identifiers

Name	2-hydroxy-1-(1H-indol-5-yl)ethanone
Synonyms	2-hydroxy-1-(1H-indol-5-yl)ethanone Ethanone, 2-hydroxy-1-(1H-indol-5-yl)-
CAS	38693-06-0
InChI	InChI=1/C10H9NO2/c12-6-10(13)8-1-2-9-7(5-8)3-4-11-9/h1-5,11-12H,6H2

Ethanone, 2-hydroxy-1-(1H-indol-5-yl)- - Physico-chemical Properties

Molecular Formula	C10H9NO2
Molar Mass	175.18
Density	1.1999 (rough estimate)
Boling Point	306.47°C (rough estimate)
Flash Point	195.2°C
Vapor Presure	4.38E-07mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.5060 (estimate)

Ethanone, 2-hydroxy-1-(1H-indol-5-yl)- - Introduction

2-hydroxy-1-(1H-indol-5-yl)ethanone is an organic compound with the chemical formula C11H9NO2. It is a pale yellow crystalline solid with a peculiar odor. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Light yellow crystalline solid
-Molecular weight: 195.20g/mol
-Melting point: 82-84°C
-Boiling Point: No data available
-Solubility: Slightly soluble in ethanol and chloroform, almost insoluble in water

Use:
2-hydroxy-1-(1H-indol-5-yl)ethanone has important application value in chemical research and can be used as reagents, intermediates or catalysts in organic synthesis reactions. It can be used to synthesize indole compounds, such as indole carboxylic acid derivatives and indole amine compounds, which have potential applications in drug research and biological activity research.

Preparation Method:
A commonly used synthesis method is to prepare 2-hydroxy-1-(1H-indol-5-yl)ethanone through an acylation reaction catalyzed by sodium acetate. Specific steps are as follows:
1. Indole is dissolved in acetic anhydride, and sodium acetate is added as a catalyst.
2. Stir the reaction solution at constant temperature for several hours.
3. After completion of the reaction, the reaction solution was diluted with water.
4. The organic phase is separated by extraction and other methods, and then purified by distillation or crystallization to obtain the target product.

Security Information:
According to current data, 2-hydroxy-1-(1H-indol-5-yl)ethanone is considered relatively safe in routine use. However, as with any chemical substance, it is still necessary to pay attention to safe handling measures, such as wearing appropriate protective equipment (such as gloves and glasses), avoiding inhalation of dust and contact with skin, eyes or mouth. In addition, the compound should be handled in a well-ventilated environment and properly stored and handled. Any specific use and safety questions are recommended to consult a chemical professional or institution.

Last Update：2024-04-09 20:52:54